Hope someone can help with this.  I have just had my second infusion of my loading dose and the day before yesterday and I am having worse symptoms than before. With the first dose I felt very tired , my stomach was noisier and bowel movements became looser.  Then I got a lot of joint pain which went after about a week.  The second dose has given me loose and frequent bowel movements and lots to stomach pain (more than before I started it).  Next dose is in 4 weeks and I have no idea when I am seeing my consultant again.  Has anyone else had this ? Should I feel worse before I feel better.  I am still on 15mg of Pred daily (I haven't been told when to start reducing it) and Methotrexate and Pentasa.   Ideas anyone ?